Dr. Shammas Publishes Paper in the Journal of Invasive Cardiology  (Posted 1/15/06) 

Dr. Nicolas Shammas has published "Eptifibatide in Peripheral Vascular Interventions:  Results of the Integrilin Reduces Inflammation in Peripheral Vascular Interventions (INFLAME) Trial" in the Journal of Invasive Cardiology, 2006:18:6-12.  This trial was a randomized, prospective study that evaluated the vascular inflammatory responses to angioplasty in the lower extremities and tested the hypothesis that integrilin, a 2b/3a inhibitor, reduces these responses.  Although integrilin did not appear to influence these markers of inflammation, it was clear that inflammation does occur post intervention and follows a predictable pathway.  A commentary by Dr. John Young, from the Ohio Heart and Vascular Center and the Lindner Center for Research and Education at the Christ Hospital, Cincinnati, Ohio, on the INFLAME trial stated that "this study raises interesting and important questions about the similarities and potentially important differences across vascular beds."  

Co-authors with Dr. Nicolas W. Shammas were Eric Dippel, MD, Jon Lemke, PhD, Jon Robken, MD, H. Lester Kirchner, MD (from Case Western Reserve University), Vickie Takes, RTR, Matthew Kapalis, BS, and Theresa Palabrica, MD (Millennium Company).  

Read the paper by clicking here.